Analytical support
The Analytical department fully supports all activities at the Reading site, including catalogue product release, evaluation of materials for in-house R&D programmes, client projects and contract analysis.
Working collaboratively within multidisciplined project teams with colleagues and clients our analytical chemists provide end-to-end support; from initial route development and optimisation to establish robust reaction schemes to target molecules, through to their final release.
Services
The analytical department provides a wide range of services
Raw material, intermediate, active pharmaceutical ingredient (API) and reference standard physico chemical evaluation, including, but not limited to, QC release of materials (both GMP and non-GMP), impurity profiling, specification development, method development, validation, method transfer and cleaning verification. In addition, we are able to provide stability trials and stress testing studies in accordance with ICH guidelines along with the preparation of documentation for regulatory filings.
Contract Laboratory Analytical Service
As well as supporting our catalogue offering, R&D activities and client-based synthesis activities we also offer Contract Laboratory Analytical Service to clients. Our on-site techniques in the UK include.
Separation sciences
- HPLC (UV, RID, DAD, ELSD)
- UHPLC (DAD, RID)
- Ion Chromatography (PAD)
- Gas Chromatography (Direct & Head Space)
- TLC
- Gel Electrophoresis
Spectrometric & Spectroscopic characterisation
- NMR (1H, 13C, 19F, 31P, COSY, HMBC, DEPT, DEPT135, DEPTQ, HMQC)
- FTIR
- UV
Elemental & Microanalysis
- Karl-Fischer
- Titrations
- Residue on ignition
- Loss on drying
Physical chemistry
- Melting point
- Polarimetry
Pricing
Analytical Testing Pricing
The following rates apply to analytical services. The set-up fee covers the first sample, with reduced rates for subsequent samples.
| Analysis Required | Non-GMP Cost per Unit | GMP Cost per Unit | ||
|---|---|---|---|---|
| Set-up Price | Subsequent Sample | Set-up Price | Subsequent Sample | |
| Impurities by HPLC * | £1,000 | £100 | £1,250 | £200 |
| Assay by HPLC * | £1,100 | £100 | £1,350 | £200 |
| Assay + Impurities by HPLC * | £1,200 | £200 | £1,450 | £300 |
| Mass Spectrometry (full scan or SIM) | £1,200 | £100 | Not available | — |
| Residual Solvents by GC (HS) * | £1,000 | £100 ** | £1,250 | £200 |
| Impurities by GC * | £1,000 | £100 | £1,250 | £200 |
| NMR — 1H, 19F 1D spectra (capture only) | £150 | £75 | £200 | £100 |
| NMR — 13C 1D, COSY, HSQC, HMBC 2D (capture only) | £200 | £125 | £250 | £150 |
| NMR — Spectra + Interpretation | £250 / hr | £300 / hr | ||
| FTIR | £150 | £50 | £250 | £75 |
| KF Water Content Determination | £150 | £50 | £200 | £75 |
Listed pricing is a general guide and may be subject to change depending on method availability, complexity of sample preparation, and the required level of data processing.
As standard, all analysis by HPLC and GC has a turnaround time of 7-10 working days, with the remaining tests being 5-7 working days. Turnaround for all tests can be reduced for additional charges.
* Additional costs may apply if method development is required, quoted case-by-case.
** Residual solvents analysis incurs an additional £50 per solvent tested.