NU003 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-thymine (D-FMAU)
NU004 5-Fluoro-1-(2′,3′-dideoxy-2′,3′-didehydro-β-D-arabinofuranosyl)-cytosine (Dexelvucitabine)
NU011 1-(2′-Deoxy-2′-fluoro-α-L-arabinofuranosyl)-thymine (alpha-Clevudine)
NU101 UDP-a-D-galactose (ammonium salt)
NU102 UDP-2-deoxy-a-D-galactose (ammonium salt)
NU103 UDP-a-N-acetyl-D-galactosamine (ammonium salt)
NU104 UDP-a-D-glucose (ammonium salt)
NU105 UDP-b-L-glucose (ammonium salt)
NU106 TDP-a-D-glucose (ammonium salt)
NU107 TDP-a-D-fucose (ammonium salt)
NU108 TDP-b-L-rhamnose (ammonium salt)
NU109 GDP-b-L-glucose (ammonium salt)
What are Nucleosides & Nucleotides?
Naturally occurring nucleosides are glycosylamines comprising of a 5-carbon ribose or 2-deoxyribose sugar bound to a nucleobase via a β-glycsidic bond. Nucleosides are the precursors to the nucleotide building blocks of DNA and RNA and can be subdivided into two classes relating to their nucleobase subunit, pyrimidines (cytidine, thymidine and uridine) and purines (guanosine and adenosine).
Nucleotides are comprised of a nucleobase, ribose or deoxyribose sugar and one or more phosphate groups. In addition to their role as fundamental building blocks of DNA and RNA, nucleotides are also key in cell metabolism (as the nucleoside triphosphates ATP, GTP, CTP and UTP) and cell signalling (cGMP and cAMP).
Synthetic Nucleosides & Nucleotides
Synthetic nucleoside and nucleotide analogues have been used successfully in the treatment of a wide range of clinical indications. Examples include azidothymidine (AZT) and abacavir in the treatment of HIV and ribavirin in the treatment of a range of viral diseases. Other indications where nucleoside analogues are used in the clinic include cancer, varicella zoster and herpes simplex.