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View Affinity Columns
Affinity Columns
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View Blood Group A
Blood Group A
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View Blood Group And Lewis Antigen Neoglycolipids
Blood Group And Lewis Antigen Neoglycolipids
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View Blood Group and Lewis Antigen Neoglycoproteins
Blood Group and Lewis Antigen Neoglycoproteins
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View Blood Group B
Blood Group B
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View Blood Group H
Blood Group H
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View Lewis Antigens
Lewis Antigens
AFF101 Blood Group A Trisaccharide Sepharose FF
AFF102 Blood group B trisaccharide Sepharose FF
AFF201 Blood group A trisaccharide Sepharose 4B
AFF202 Blood group B trisaccharide Sepharose 4B
G323 Blood group B trisaccharide
G324 Blood group B trisaccharide amine derivative
G326 Blood group B trisaccharide ester derivative
G421 Blood group B type 1 tetrasaccharide
G422 Blood group B type 2 tetrasaccharide
G423 Blood group B type 3/4 tetrasaccharide
G431 Blood group B type 1 tetrasaccharide-NGL
G432 Blood group B type 2 tetrasaccharide-NGL
G433 Blood group B type 3 tetrasaccharide-NGL
G434 Blood group B type 4 tetrasaccharide-NGL
G525 Blood group B pentasaccharide
GN333 Blood group B type 1 linear trisaccharide
GN334 Blood group B type 2 linear trisaccharide
GN335 Blood group B type 3/4 linear trisaccharide
GN343 Blood group B type 1 linear trisaccharide-NGL
GN344 Blood group B type 2 linear trisaccharide-NGL
GN345 Blood group A type 3 linear trisaccharide-NGL
GN346 Blood group A type 1 linear trisaccharide-NGL
L141 Blood group A type 1 tetrasaccharide
L142 Blood group A type 2 tetrasaccharide
L143 Blood group A type 3/4 tetrasaccharide
More Information
The Blood Typing System & Carbohydrates
The discovery of the ABO blood typing system by Karl Landsteiner over 100 years ago and the subsequent elucidation of their carbohydrate structures by Walter Morgan were exceedingly important milestones in the progression of modern medicine.
The ABO is system is the most important of the many blood typing systems and is of the utmost importance in transfusion and transplantation medicine. If patients receive a transfusion of incompatible blood, an acute haemolytic reaction can occur, this can lead to death.
The blood group antigens are oligosaccharides expressed on the surface of red blood cells and are determined by the terminal saccharides. The biosynthesis is effected via the action of the A or B glycosyltransferase on the H antigen, to form the A or B glycan. The H antigen remains unmodified in individuals lacking either of these glycosyltransferases, resulting in an individual with blood type O. The expression of these antigens is not limited to red blood cells and also occurs on epithelial and other cells.
Blood groups are determined by the ABO gene, which encodes the glycosyltransferase which forms the A, B and H antigens. The alleles for the A and B blood types show co-dominance, whilst the blood group O allele is recessive, giving rise to the familiar four ABO blood types.