February 22, 2024

Glycosyltransferases in Colorectal Cancer

Glycosylation in CRC can affect cell migration, cell-cell adhesion, actin polymerization, mitosis, cell membrane repair, apoptosis, cell differentiation, stemness regulation, intestinal mucosal barrier integrity, immune system regulation, T cell polarization and gut microbiota composition; all such functions are associated with the prognosis and evolution of the disease.

Multiple strategies have been evaluated to alter oligosaccharide processing and to modify glycoconjugate structures in order to control CRC progression and prevent metastasis.

For example, Sialyl-Tn is a carbohydrate antigen overexpressed in several epithelial cancers including breast cancer, and is usually associated with poor prognosis.

Take a look at our antigen conjugate database: