We have an extensive collection of imino sugars from natural sources available on request. We can also offer semi-synthetic modifications of the natural products. Those listed on our website cover the most common natural products such as DNJ, DAB and DMDP, which are all broad spectrum and potent alpha-glucosidase inhibitors.
We also have calystegines which are specific beta-glucosidase and galactosidase inhibitors. Swainsonine is the best known of the alpha-mannosidase inhibitors and is a bicyclic indolizidine alkaloid, as is castanospermine, an alpha- and beta-glucosidase inhibitor.
The imino sugars can be very specific in their glucosidase inhibition, even, for example, amongst alpha-glucosidases. Their stability is high even in biological systems. Most appear to be readily bioavailable orally and are primarily excreted unchanged in urine.